Lipid raft-targeted Akt promotes axonal branching and growth cone expansion via mTOR and Rac1, respectively
نویسندگان
چکیده
منابع مشابه
PI3K regulates branch initiation and extension of cultured mammary epithelia via Akt and Rac1 respectively.
The tree-like architecture of the mammary gland is generated by branching morphogenesis, which is regulated by many signals from the microenvironment. Here we examined how signaling downstream of phosphoinositide 3-kinase (PI3K) regulates different steps of mammary branching using three-dimensional culture models of the mammary epithelial duct. We found that PI3K was required for both branch in...
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During the establishment of neural circuits, the axons of neurons grow towards their target regions in response to both positive and negative stimuli. Because recent reports show that Ca2+ transients in growth cones negatively regulate axonal growth, we studied how ionotropic ATP receptors (P2X) might participate in this process. Our results show that exposing cultured hippocampal neurons to AT...
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ژورنال
عنوان ژورنال: Journal of Neuroscience Research
سال: 2009
ISSN: 0360-4012,1097-4547
DOI: 10.1002/jnr.22140